Welcome to the Walczak Lab
Our lab is interested in the fundamental mechanisms that cells use to accurately distribute their genetic material to the two daughter cells. Defects in this process lead to aneuploidy and genomic instability, which are hallmarks of cancer. We use a combination of approaches, including high-resolution imaging, biochemistry, genomics and cell/molecular biology to ask fundamental questions about how cells maintain mitotic fidelity and how cell maintain proper ploidy using both normal and tumor cell models.
Cells use multiple mechanisms to prevent aneuploidy. One emerging idea is that cancer cells thrive with low levels of aneuploidy, which allows for phenotype evolution. However, higher levels of aneuploidy lead to failure in cell division and cell death. We are currently exploring multiple pathways that contribute to aneuploidy and identifying the key players that can be targeted to cause high levels of aneuploidy and thus provide in-roads for new mechanisms of therapeutic development.
The dynamic microtubules are critical for spindle function and are also the targets of several anti-neoplastic agents that are front-line treatments for multiple types of cancers. However, side effects can be severe and result in discontinuation of treatment. In addition, development of resistance is common. Several of the proteins we study are highly overexpressed in multiple cancer types, which correlates with poor prognosis. Thus, we are developing screening assays that can be used to identify new drugs that target these microtubule regulators as well as trying to understand how their expression correlates with drug resistance and poor prognosis.
Professor of Biochemistry and Molecular Biology, Medical Sciences, Indiana University School of Medicine-BL
BS Chemistry, Rensselaer Polytechnic Institute
PhD Biochemistry, University of Wisconsin-Madison
Post-doctoral Fellow, University of California-San Francisco
Asst. Research Professor, Medical Sciences,
Indiana University School of Medicine-BL
BS Biology, Indiana University
PhD Medical and Molecular Genetics, Indiana University School of Medicine
Post-doctoral Fellow, Indiana University
Post-doctoral Fellow, Medical Sciences,
Indiana University School of Medicine-BL
BS Biochemistry, Dhaka University
MS Biochemistry, Dhaka University
PhD Molecular Biology, New Mexico State University
Post-doctoral Fellow, National Institutes of Health
Medical Sciences, Indiana University School of Medicine-BL
BS Biochemistry, Indiana University
MS Biotechnology, Indiana University
Penn State University
CMCB Graduate Student
BS Molecular Cell Biology
BS Human Biology 2020
BS Biology 2021
BS Biology 2023
BS Molecular Life Sciences 2023
Former Lab Members
Walczak Lab Skating 2020
Congratulations Stephanie on two great new papers!
Female Genius Lab!
Congratulations Kelly for her recent Current Biology review!
Congratulations Claire for the NIH Supplement
Can't Wait to Image on that New Microscope
Congratulations Kelly on Receiving a QCB Fellowships
Congratulations Benny and Katie on welcoming Baby Ilse to your family
Great Job at the IU SSRP Symposium
Aisha and Jacob
Great Job Jared, Stephanie, Kenzie, Jason and Kendra at the HHC Research Symposium
Congratulations Claire on being elected an AAAS Fellow
Welcome Rotation Students Natasha and Ahmed to the lab
Congratulations to Claire on being elected as a Fellow of the American Society for Cell Biology!
Welcome visiting student Serena Mahnoor.
Welcome Kendra Lambert to the Lab, Biotechnology MS Student.
Congratulations Dr. Amber Yount
Hutton Honors College Undergraduate Research Symposium
Great Job Jeanna, Jason, Kenzie, Stephanie, and Mark
Walczak Lab Skating Trip
Happy Birthday Kenzie and Jason
Congratulations to Hailing Zong on successfully defending her PhD
Welcome Stephanie Zhang to the lab
Congratulations to Shengyao Chen on successfully defending his PhD
Welcome Kenzie Emch to the Lab
Congratulations Claire and Brian on their CTSI Core Pilot Proprosal.
Congratulations to Claire on Recognition of Professionalism and integrity in research by The Research Exemplar Project.
Welcome Mark Hazelbaker and Jeanna Wigley to the Lab